Untitled Document

PRIORITY AREA 2

Cheminformatics and de novo synthesis.

Cheminformatics research ahould include:

data handling of pertinent finding of biomolecule research ranging from initial studies using crude extracts through fractionated etracts to lead compounds and modified biomolecules

analysis of the above data particularly the use of structure-activity relationship in rational drug design

chemical modelling of biomolecule-receptor interactionated extracts leading to predictions of structure for potential drug candidates.

development towards virtual screening capabilities based on the research in the preceding components.

The de novo drug synthesis should focus on:

the application of combinatorial chemistry to produce a wide range of analogues for screening as potential drug candidates.

the efficient use of synthetic chemistry to produce modifications in the molecular structures of bioactive compounds leading to novel entities.

the application of biological techniques in the generation of novel biomolecules.

The pharmacological systems of the biomolecules for this area of research should be aligned to the systems outlined under priority area 1.

@ Hak cipta terpelihara BIOTEK



		PRIORITY AREA 2 Cheminformatics and de novo synthesis. Cheminformatics research ahould include: data handling of pertinent finding of biomolecule research ranging from initial studies using crude extracts through fractionated etracts to lead compounds and modified biomolecules analysis of the above data particularly the use of structure-activity relationship in rational drug design chemical modelling of biomolecule-receptor interactionated extracts leading to predictions of structure for potential drug candidates. development towards virtual screening capabilities based on the research in the preceding components. The de novo drug synthesis should focus on: the application of combinatorial chemistry to produce a wide range of analogues for screening as potential drug candidates. the efficient use of synthetic chemistry to produce modifications in the molecular structures of bioactive compounds leading to novel entities. the application of biological techniques in the generation of novel biomolecules. The pharmacological systems of the biomolecules for this area of research should be aligned to the systems outlined under priority area 1.

@ Hak cipta terpelihara BIOTEK