Executive summary

This research project is proposed with the view to develop, integrate and enrich USM's drug discovery and development initiative with special reference to anti-bacterial erythromycin B. The duration of this project is for three years. This research endeavour will bring together researchers from many related disciplines in a joint effort to discover potential biopharmaceuticals from bacteria S. erythraea. Research activities will include metabolic engineering, production of metabolites from the cloned bacteria, metabolism, molecular modeling, bioinformatic and NMR screening. These strategies will provide a unique opportunity for smart partnership within and outside USM to jump start biopharmaceutical research in Malaysia in a collaborative approach and to further stimulate the development of the local biopharmaceutical industry. These objectives are achieved through a network of strategic alliances among research scientists from various academic institutions such as Universiti Sains Malaysia, Universiti Teknologi Malaysia, Universiti Malaya and Universiti Kebangsaan Malaysia and also from industry partnership.

Project Title:

Drug development and discovery of erythromycin B and its analogs:
NMR and computational approach

 

This project will serve as a core facility to bring together a wide range of scientific disciplines in a productive collaboration to apply state of the art technologies, fostering new knowledge and skills and advancing our country's goal in developing our local biopharmaceutical industry. Our research platform will allow and provide us with the opportunity to synergistically combine areas of expertise, resources, leverage the technological platform and provide product (leads) commercialization opportunities for our research cluster.

Period of the project : 3 Years (2003 - 2005)

Project Status

- On-going